Arthritis, a painful disease of the joints, can be the result of a medical condition, a physical injury, or aging. Thankfully, cannabis and CBD are being investigated as treatments for arthritis. Below are some of the active clinical trials and published papers on cannabis for the treatment of arthritis.
Active Clinical Trials on Arthritis and Cannabis
- Cannabinoid Profile Investigation of Vapourized Cannabis in Patients With Osteoarthritis of the Knee (CAPRI) – Recruiting Patients in Canada via McGill University
Published Clinical Research Studies in Humans on Arthritis and the Endocannabinoid System
- Expression of cannabinoid receptors in human osteoarthritic cartilage: implications for future therapies (2016)
- Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain (2015)
- Endocannabinoids and acute pain after total knee arthroplasty (2015)
- Leptin levels are negatively correlated with 2-
arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis (2015) - Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis (2006)
Published Research Studies in Animals on Arthritis and the Endocannabinoid System
- Transdermal cannabidiol reduces inflammation and pain-related
behaviours in a rat model of arthritis (2015) - HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid (2015)
- The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion (2015)
- The abnormal cannabidiol
analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 (2011) - A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with
antiinflammatory properties in murine collagen-induced arthritis (2004) Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw (2004)- The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis (2000)
Published Review Papers on Arthritis and the Endocannabinoid System
- Efficacy, Tolerability, and Safety of Cannabinoid Treatments in the Rheumatic Diseases: A Systematic Review of Randomized Controlled Trials (2016)
- Efficacy, tolerability
and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis): A systematic review of randomized controlled trials (2016) - Involvement of the endocannabinoid system in osteoarthritis pain (2014)
- Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials(2011)
- Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (2011)
- Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine (2007)
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