• Health
  • Nutrition
  • Cannabis
  • Beauty
  • Fitness
  • Life
  • Nav Social Icons

  • Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer
  • Meet Dr. Ross
    • Interviews
  • Services
    • Business Consulting
    • Influencer Marketing
    • Speaking
  • Books
  • Courses
  • Consultations
  • Blog
    • Health
    • Nutrition
    • Cannabis
    • Beauty
    • Fitness
    • Life
  • Contact
  • Mobile Menu Widgets

    Connect

    Search

Cannabis Doctor Michele Ross Marijuana Expert

Dr. Michele Ross

Cannabis Coach & Cannabis Consulting

  • Meet Dr. Ross
    • About Dr. Ross
    • Press Coverage
  • Services
    • Advertising
    • Business Consulting
    • Influencer Marketing
    • Speaking
  • Contact
  • Books
    • Vitamin Weed
    • CBD Oil For Health
    • Kratom Is Medicine
    • Train Your Brain To Get Thin
    • Journal Yourself To Health
  • Courses
    • Cannabis & Motherhood
    • Cannabis For Pelvic Pain
    • Cannabis For Migraine
    • Cannabis For Fibromyalgia
  • Consults
Dr. Ross > Health > New Weight Loss Drugs Target the Endocannabinoid System

New Weight Loss Drugs Target the Endocannabinoid System

By: Michele Ross, PhD · Published On: August 18, 2020 · Last Updated: October 19, 2022

woman scientist developing weight loss drug
Pin
Share
Tweet
Share
Email

The endocannabinoid system is involved in many pathways in the body, including regulation of appetite and fat burning. Anyone who has experienced “the munchies” can attest to the fact that many cannabis strains and edibles with THC can increase hunger. Hunger is increased by activating the endocannabinoid system, and thus scientists thought blocking the endocannabinoid system with drugs could decrease hunger and increase weight loss.

The Opposite of The Munchies

Rimonabant was a first-generation inhibitor of cannabinoid type 1 (CB1) receptors, working both in the brain and the body. It was first approved in Europe in 2006 and was taken off the market in 2008 due to psychiatric side effects in 10% of patients including suicidal thoughts that outweighed its medical benefits as a weight loss drug. It was never approved as a drug in the United States.

read vitamin weed by dr michele ross neuroscientist

A second-generation of CB1 inhibitors have been developed, this time working only on peripheral cannabinoid receptors and not crossing the blood-brain barrier. These second-generation drugs, like AM6545, do not have the same psychiatric side effects rimonabant does but reduce elevated metabolic parameters including cholesterol and insulin.

Rimonabant also induced nausea and vomiting, while AM6545 has minimal nausea side effects. AM6545 only decreased weight in mice that are obese due to a high-fat diet, and not normal mice. This is important because it shows CB1 inhibitors will not be abused by normal weight or underweight patients looking to drop 10 pounds in a week.

It may take many years for these drugs to show efficacy in human clinical trials and be approved as a prescription by the United States Food & Drug Administration, or FDA. Until then, other cannabinoids including CBD and THCV have shown efficacy in weight loss and are available in many hemp and cannabis products.

References

Tam, J., et al., Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest, 2010. 120(8): p. 2953-66.

Pin This Post

rimonabant psychiatric problems cb1 inhibitor

Share This Post

New Weight Loss Drugs Target the Endocannabinoid System
Pin
Share
Tweet
Share
Email

By: Michele Ross, PhD · In: Health · Tagged: CBD, cholesterol, clinical research, FDA, weight loss

Cannabis Expert Cannabis Consultant Psychedelic Expert Dr. Michele Ross

About Michele Ross, PhD

Dr. Michele Ross is a neuroscientist helping women heal chronic pain with alternative medicine. She is the author of Kratom is Medicine, Vitamin Weed, CBD Oil For Health, and Train Your Brain To Get Thin and the CEO of Infused Partners.

you’ll also love

black eye doctor talk to female patient about vision in medical checkup4 Medical Checkups and Tests You Shouldn’t Miss Each Year
woman with OCD talking to her therapist6 Risk Factors For Developing Obsessive-Compulsive Disorder (OCD)
pot leaf cannabis shop medical marijuana dispensary in reno nevada4 Frequently Asked Questions About Medical and Recreational Cannabis Dispensaries

Join the List

Stay up to date & receive the latest posts in your inbox.

Next Post >

7 Benefits of Smoking Hemp Flower

Primary Sidebar

Meet Dr. Ross

Meet Dr. Ross
hello!

I help women heal pain using plant medicines including cannabis and mushrooms.

Learn more

Connect

join the list

Featured Posts

black woman athlete working out used cbd oil

Why Athletes Choose CBD For Faster Recovery From Workouts

watermelon vape flavor is popular

7 Most Popular Vape Flavors To Smoke

woman buying cannabis at a marijuana dispensary and outdoor weed market

An Insider’s Look at the Benefits of Shopping at a Dispensary

Categories

  • Health
  • Nutrition
  • Cannabis
  • Beauty
  • Fitness
  • Life

Search

ready to get started?

I can't wait to work with you!

I've been working with plant medicine for over 15 years, written 5 books, and spoken around the world. I know the ins & outs of what makes a good product and which ones you or your clients should be taking.

Education Services

follow @drmicheleross

I’m on the Threads app! Come follow me @drmichel I’m on the Threads app! Come follow me @drmicheleross there too. It’s like Twitter but better.

#fibromyalgiaawareness #painreliefoptions #healthcoaching #herbalistlife #neuroscientist
So excited to share that I was interviewed about S So excited to share that I was interviewed about S@x and Psilocyb!n Mushr00ms for Jennifer Chesak’s new book “The Psilocyb!n Handbook for Women.” 

Not going to give any spoilers…but our conversation might surprise you in a good way.

Ladies, this book is a fun read that gives you the details on what’s really important for us…mushr00ms are more than Silicon Valley bros trying to get more work done, people looking for help with intense addictions, and rave kiddos tripping every weekend.

This is a must read! Link in bi0.

#witchystuff #sexystuff #womenover40 #healingtrauma #healingjourney
Happy Mother’s Day! Give your liver a break and Happy Mother’s Day! Give your liver a break and keep your breasts cancer-free by choosing healthier ways to relax and celebrate instead of alcohol.

I can’t dive too deep into specifics here on Instagram, but just know there are natural, plant-based substances full of antioxidants & they can fight inflammation, rewire your brain & release trauma, and relieve pain. 

Or they can just put you in your happy place for that brief & rare moment you have some time to yourself away from the kiddos.

Just know I am always here to hold a safe, supportive & non-judgmental container for you to explore relaxation, relief, and even JOY in every form. 🌈💚🍄

P.S. Lucky moms, check out my link in bio for a special Mother’s Day offer.

#mothersdaygiftideas #happymothersday❤️ #happymotherday #happymothersday2023 #sobercurious
You don’t have to struggle alone. Fibromyalgia i You don’t have to struggle alone. Fibromyalgia is REAL. and there are many options your doctor hasn’t heard of that work. Visit link in bio to start your fibromyalgia recovery💜. PS we have a huge launch coming in June!!!

#fibromyalgiaawarenessday #fibromyalgiaawarenessmonth
#fibromyalgia
#cynthiahealth
#drmicheleross
Happy International Women's Day to all the women c Happy International Women's Day to all the women crushing it despite getting less pay, less startup funding, less everything when it comes to business. Let's do more than recognize women.

In 2023, it's time to:
*Buy from women-owned businesses
*Give women a seat at the table, preferably the board
*End all male speaking panels
*Invest in women startups, including those focused on serving women
*Include more women in clinical trials
*End toxic work cultures
*Support paid maternity leave policies
*Fill the wage gap between men and women
*Donate to nonprofits serving women
*Let women take time off of work for painful periods without stigma or penalty
*Work harder to specifically include and apply all of these principles to women from marginalized groups such as black women, disabled women, LGBTQ women, and females identifying as nonbinary, genderfluid, or genderqueer.

And so. much. more.

#internationalwomensday #womensday2023 #internationalwomensday2023 #womenfounders
#investinwomen

Footer

On the Blog

  • Health
  • Nutrition
  • Cannabis
  • Beauty
  • Fitness
  • Life

Legal

  • Privacy Policy
  • Terms of Use
  • Affiliate Disclosure
  • Advertising
  • Careers
  • Contact

Next Steps

  • Book a Consult
  • Shop Books & Courses
  • Infused Partners Brands
  • Shop AURA Kratom
  • Join MushroomMD
  • Join Chronically Healing

© 2023 Infused Partners. This website is for informational and entertainment purposes only and is not a substitute for medical advice, diagnosis or treatment.